Seralutinib New
Data Sheet
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| CAS No. | 1619931-27-9 | Cat. No. | BCP39880 |
| Name | Seralutinib | ||
| Synonyms | PK-10571; PK10571; PK 10571; GB002; GB-002; GB 002; | ||
| SMILES | CC1=CC(=CN=C1)C(=O)NC2=CC=CC(=C2)C(C)NC3=NC(=CN=C3)C4=CC(=C(C=C4)OC)OC | ||
| Chemical Name | |||
| Formula | C27H27N5O3 | M. Wt | 469.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Seralutinibm, also known as PK-10571 and GB002, is a Novel Inhaled PDGFR Kinase Inhibitor. Seralutinib demonstrates efficacy in the Su5416 Hypoxia Rat Model of Pulmonary Arterial Hypertension (pah). Localized delivery of GB002 is efficacious on multiple measures of disease activity in the SU5416/H model. GB002 treatment is associated with disease remodeling including improved cardiopulmonary hemodynamics, reduced pulmonary arteriolar muscularization, restoration of BMPR2 signaling, reduced NT-proBNP and improved cytokines. | ||
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