Lirafugratinib New
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| CAS No. | 2549174-42-5 | Cat. No. | BCP49189 |
| Name | Lirafugratinib | ||
| Synonyms | FGFR2-IN-3;RLY-4008;RLY4008;RLY 4008; | ||
| SMILES | CC1=NC(=NC=C1)OC2=C(C=C(C=C2)C3=C(N(C4=NC=NC(=C34)N)C)C5=CC=C(C=C5)NC(=O)C(=C)C)F | ||
| Chemical Name | |||
| Formula | C28H24FN7O2 | M. Wt | 509.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Lirafugratinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival. | ||
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