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AL082D06 Chemical Structure

AL082D06

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28760CAS No. :256925-03-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 256925-03-8 Cat. No. BCP28760
Name AL082D06
Synonyms AL-082D06; AL 082D06;D06;D 06; D-06;
SMILES O=[N+](C1=CC=C(Cl)C(C(C2=CC=C(N(C)C)C=C2)C3=CC=C(N(C)C)C=C3)=C1)[O-]
Chemical Name
Formula C23H24ClN3O2 M. Wt 409.91
Purity 98% Storage Store at 4-8°C
Description AL082D06, also known as D-06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid-mediated transcriptional regulation. AL082D06 binds competitively with steroids, likely occupying a similar site within the ligand-binding domain.
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