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ARV393 Chemical Structure

ARV393

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP49670CAS No. ：2851885-95-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2851885-95-3 Cat. No. BCP49670
Name ARV393
Synonyms ARV-393;ARV 393;
SMILES
Chemical Name
Formula C46H53ClFN9O7 M. Wt 898.42
Purity 98% Storage Store at 4-8°C
Description ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.
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