AIM-100
| CAS No. | 873305-35-2 | Cat. No. | BCP35051 |
| Name | AIM-100 | ||
| Synonyms | AIM 100; AIM100; | ||
| Formula | C23H21N3O2 | M. Wt | 371.44 |
| Description | AIM-100 is a potent and selective Ack1 tyrosine kinase with IC50 value of 24 nM. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
Structure
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