依帕斯他

  • 化学数据
CAS号 82159-09-9 货号 BCP04572
中文名 依帕斯他
英文名 Epalrestat
中文别名 益帕瑞司特; 依帕司他;
英文别名 ONO-2235; ONO 2235; ONO2235; Sorbistat;
分子式 C15H13NO3S2 分子量 319.39
  • 用途
生物活性 Epalrestat may affect or delay progression of the underlying disease process. Data from six clinical trials were evaluated, and it was determined that epalrestat 50 mg 3 times/day may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms as compared with baseline and placebo. Epalrestat may serve as a new therapeutic option to prevent or slow the progression of diabetic neuropathy. Epalrestat significantly increased the amplitude of 3 cpm waves on EGG and improved the spectral analytical parameters of heart rate variability. These findings suggest that epalrestat is useful for the treatment of diabetic gastroparesis . Epalrestat is a highly effective and safe agent for the treatment of diabetic neuropathy .
信号通路 Protease/Metabolic Enzyme 
靶 点 Aldose Reductase 

结构式

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