异甘草素
| CAS号 | 961-29-5 | 货号 | BCP02312 |
| 中文名 | 异甘草素 | ||
| 英文名 | Isoliquiritigenin | ||
| 中文别名 | |||
| 英文别名 | GU17;ISL;Isoliquiritigen;GU 17;GU-17; | ||
| 分子式 | C15H12O4 | 分子量 | 256.25 |
| 生物活性 | Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM.Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). | ||
| 信号通路 | Protease/Metabolic Enzyme Hormone Pathay | ||
| 靶 点 | Estrogen Receptor Aldose Reductase | ||
结构式
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