利拉利汀
| CAS号 | 668270-12-0 | 货号 | BCP02462 |
| 中文名 | 利拉利汀 | ||
| 英文名 | Linagliptin | ||
| 中文别名 | |||
| 英文别名 | BI 1356;Tradjenta;BI-1356;BI1356; | ||
| 分子式 | C25H28N8O2 | 分子量 | 472.54 |
| 生物活性 | Linagliptin shows a potent inhibition effect against DPP-4 in vitro and a low affinity for hERG channel and M1 receptor (IC50 295 nM). Linagliptin acts as a competitive inhibitor with a Ki of 1 nM, and also shows 10,000-fold more selectivity for DPP-4 than DPP-8, DPP-9, amino-peptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin, and 90-fold more selectivity than fibroblast activation protein in vitro. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | DPP | ||
结构式
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