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Taletrectinib adipate Chemical Structure

Taletrectinib adipate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP34720CAS No. :1505515-69-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1505515-69-4 Cat. No. BCP34720
Name Taletrectinib adipate
Synonyms DS-6051B adipate; AB-106 adipate;
SMILES CC(COC1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NC(C)C4=CC(=CC=C4)F)N.C(CCC(=O)O)CC(=O)O
Chemical Name
Formula C29H34FN5O5 M. Wt 551.62
Purity 98% Storage Store at 4-8°C
Description Taletrectinib is an orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, DS-6051b binds to and inhibits ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements play a key role in cancer progression.
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