Taletrectinib adipate
| CAS No. | 1505515-69-4 | Cat. No. | BCP34720 |
| Name | Taletrectinib adipate | ||
| Synonyms | DS-6051B adipate; AB-106 adipate; | ||
| Formula | C29H34FN5O5 | M. Wt | 551.62 |
| Description | Taletrectinib is an orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, DS-6051b binds to and inhibits ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements play a key role in cancer progression. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
Structure
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