戈利昔替尼
| CAS号 | 2091134-68-6 | 货号 | BCP36112 |
| 中文名 | 戈利昔替尼 | ||
| 英文名 | Golidocitinib | ||
| 中文别名 | |||
| 英文别名 | AZD4205; AZD 4205;AZD-4205; | ||
| 分子式 | C25H29N9O2 | 分子量 | 487.57 |
| 生物活性 | Golidocitinib is an orally available inhibitor of Janus-associated kinase 1 (JAK1), with potential antineoplastic activity. Upon oral administration, golidocitinib inhibits JAK-dependent signaling and may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types. Additionally, JAK1 may be a primary driver of STAT3 phosphorylation and signaling, which plays a role in neoplastic transformation, resistance to apoptosis, tumor angiogenesis, metastasis, immune evasion, and treatment resistance. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| 靶 点 | JAK | ||
结构式
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