RMC-5127
| CAS No. | RMC-5127 | Cat. No. | BCP49725 |
| Name | RMC-5127 | ||
| Synonyms | RMC5127;RMC 5127; | ||
| Formula | C57H75N9O9S | M. Wt | 1062.33 |
| Description | RMC-5127 is an orally active and brain-penetrant mutant-selective tri-complex RASG12V inhibitor. RMC-5127 non-covalently binds to cyclophilin A (CypA), forming a binary complex that engages RASG12V(ON) to form a high-affinity tri-complex, sterically inhibiting RAS binding . RMC-5127 inhibits the RAS pathway in KRASG12V mutant cancer cells, reducing cell proliferation and inducing apoptosis. RMC-5127 is promising for research of cancers with RAS mutations, such as non-small cell lung cancer. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.