RMC-5127 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | RMC-5127 | Cat. No. | BCP49725 |
| Name | RMC-5127 | ||
| Synonyms | RMC5127;RMC 5127; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C57H75N9O9S | M. Wt | 1062.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RMC-5127 is an orally active and brain-penetrant mutant-selective tri-complex RASG12V inhibitor. RMC-5127 non-covalently binds to cyclophilin A (CypA), forming a binary complex that engages RASG12V(ON) to form a high-affinity tri-complex, sterically inhibiting RAS binding . RMC-5127 inhibits the RAS pathway in KRASG12V mutant cancer cells, reducing cell proliferation and inducing apoptosis. RMC-5127 is promising for research of cancers with RAS mutations, such as non-small cell lung cancer. | ||
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