Larotaxel

CAS No.	156294-36-9	Cat. No.	BCP27660
Name	Larotaxel
Synonyms	TAX-109;TAX 109;TAX109;XRP-9881;XRP 9881;XRP9881;RPR-109881A;PNU 100940;PNU-100940;PNU100940;192573-38-9(2H2O);
Formula	C45H53NO14	M. Wt	831.91

Description	Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.
Pathways	Cell Cycle/DNA Damage
Targets	Microtubule

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