雷尼司他
| CAS号 | 147254-64-6 | 货号 | BCP14386 |
| 中文名 | 雷尼司他 | ||
| 英文名 | Ranirestat | ||
| 中文别名 | |||
| 英文别名 | AS-3201; AS3201; AS 3201; SX-3201; SX3201; SX 3201; | ||
| 分子式 | C17H11BrFN3O4 | 分子量 | 420.19 |
| 生物活性 | Ranirestat, also known as AS-3201; SX-3201, is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin. It has been granted orphan drug status. The drug is to be used orally. Aldose reductase is an enzyme that catalyzes one of the steps in sorbitol (polyol) pathway which is responsible for formation of fructose from glucose. Aldose reductase activity is increased, parallel to glucose blood levels, in tissues that are not insulin sensitive, including lenses, peripheral nerves and renal glomeruli. Sorbitol does not diffuse through cell membranes easily and therefore accumulates in these tissues, causing osmotic damage, leading to retinopathy and neuropathy. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Aldose Reductase | ||
结构式
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