Troparil

CAS No.	74163-84-1	Cat. No.	BCP18912
Name	Troparil
Synonyms	(–)-2β-Carbomethoxy-3β-phenyltropane; WIN 35,065-2; β-CPT;
Formula	C16H21NO2	M. Wt	259.34

Description	Troparil (also known as (–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT) is a stimulant drug used in scientific research. Troparil is a phenyltropane-based dopamine reuptake inhibitor (DRI) that is derived from methylecgonidine. Troparil is a few times more potent than cocaine as a dopamine reuptake inhibitor, but is less potent as a serotonin reuptake inhibitor,and has a duration spanning a few times longer, since the phenyl ring is directly connected to the tropane ring through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine. The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	Dopamine Receptor

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