RSV604
| CAS号 | 676128-63-5 | 货号 | BCP19830 |
| 中文名 | RSV604 | ||
| 英文名 | RSV604 | ||
| 中文别名 | |||
| 英文别名 | A-60444; RSV-604; A60444; RSV 604; A 60444; | ||
| 分子式 | C22H17FN4O2 | 分子量 | 388.40 |
| 生物活性 | RSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | RSV | ||
结构式
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