RSV604

参考资料仅供科学研究，不可用于个人用途。

货号：BCP19830CAS号：676128-63-5纯度：98%

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CAS号	676128-63-5	货号	BCP19830
中文名	RSV604
英文名	RSV604
中文别名
英文别名	A-60444; RSV-604; A60444; RSV 604; A 60444;
SMILES
化学名称
分子式	C22H17FN4O2	分子量	388.40
纯度	98%	配送	惯例下常温包邮
产品描述	RSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease.